Almost half of patients with fractures (42.9%) had at least 2 comorbidities. Results Among the 307 870 participants identified with incident fractures, 95 372 were men (31.0% mean age at fracture, 72.3 years) and 212 498 were women (69.0% mean age at fracture, 74.9 years). Relative survival analysis was used to quantify excess mortality associated with the combination of multimorbidity and fractures at specific sites. Latent class analysis was conducted to identify multimorbidity clusters. Death was ascertained from the Danish Register on Causes of Death. Main Outcomes and Measures Fracture and 32 predefined chronic diseases recorded within 5 years before the index fracture were identified from the Danish National Hospital Discharge Register.

Data were analyzed from February 1 to March 31, 2022. Objective To define multimorbidity clusters at the time of fracture and quantify the interaction between multimorbidity and fracture in association with postfracture excess mortality.ĭesign, Setting, and Participants This nationwide cohort study included 307 870 adults in Denmark born on or before January 1, 1951, who had an incident low-trauma fracture between January 1, 2001, and December 31, 2014, and were followed up through December 31, 2016. Because comorbidities are common among patients 50 years and older with fractures, these fractures provide a useful setting for studying interactions among disorders.

Importance Limited knowledge about interactions among health disorders impedes optimal patient care. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.

Endnote 20 class not registered